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“A study done at Duke University shows that with the help of this treatment combination, those with mild muscle spasms may have a healthier, muscular life,” said Dr. Dario Narducci, director of the MGH Center for Aging and the Aging of Patients at MGH. “Lethal injections of the drug could eventually improve the quality of life for patients with motor neuron disease, or people who suffer from debilitating muscle spasms.
“Lethal injections of this powerful drug could save a great deal of pain and suffering for people with debilitating muscle spasms like those associated with amyotrophic lateral sclerosis (ALS),” said Narducci, who holds the William G. Leavitt Chair in ALS at MGH.
This study was supported by the National Institutes of Health (DA039559, DA048654, T32GM068306, R21 GM087800-0033, T32GM025953, DA056613, P01-GM023539, P02-DA028193 and T32GM07837).
MGH has published its own study in August in the Journal of Neuroscience. It was based on data collected in a clinical trial at the Duke VA Medical Center that tested the efficacy of lethal injection in alleviating the cognitive and behavioral symptoms experienced in patients undergoing early-stage motor neuron disease. The study, led by Narducci and coauthor Dr. Bruce H. Stodden, MD, professor of neurology and psychiatry in the Duke Medical School Center for Aging and the Aging of Patients, assessed the cognitive aspects of the patients from March 2011 through October 2013 and found that patients with ALS experienced greater cognitive impairment than those without ALS on standardized tests of reasoning and concentration.
The researchers found that the severity of ALS symptoms depended on the stage of the disease. For example, patients with stage 1 ALS had more severe cognitive impairments than patients with stage 2 ALS.
“Although lethal injection offers hope for a meaningful improvement in some patients with ALS, we have to continue to explore the safety, efficacy and adverse effects of this drug in order to identify what effect lethality may have on patients,” said Narducci.
This report was presented at the Annual Meeting of the American Association for the Study of Pain August 7, 2017 in San Jose, CA.
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The MGH Center for Aging and the Aging of Patients (CARP) is a multidisciplinary program that provides advanced diagnostic,
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